New research published by a team of researchers from the University of Toronto in collaboration with colleagues from the University of Alberta has found that women who have had both ovaries surgically removed before the age of 50 and carry a variant of the apolipoprotein gene, the APOE4 allele, are at high risk of late-life Alzheimer disease (AD).
University of TorontoDec 5 2024 New research published by a team of researchers from the University of Toronto in collaboration with colleagues from the University of Alberta has found that women who have had both ovaries surgically removed before the age of 50 and carry a variant of the apolipoprotein gene, the APOE4 allele, are at high risk of late-life Alzheimer disease . Use of hormone therapy mitigates this risk.By 2050, Alzheimer's disease is projected to affect 12.
One of our most important findings was the fact that loss of the naturally occurring hormone , estradiol, as a result of surgical removal of both ovaries, might interact with the APOE4 allele to further increase Alzheimer's disease risk, placing women with early bilateral oophorectomy and APOE4 in a state of double jeopardy."
The study also identified resilience factors associated with the risk of Alzheimer's disease for these women. A high level of education was linked to a 9% lower likelihood of developing Alzheimer's disease in women with both types of menopause -; that caused by ovarian removal and that caused by aging -; supporting previous research showing education as a form of cognitive resilience in both women and men.
Importantly, among women with early bilateral oophorectomy, ever taking hormone therapy was associated with less than half the odds of Alzheimer's disease compared to those women who had not taken hormone therapy.
Allele Alzheimer's Disease Apolipoprotein Brain Education Estradiol Gene Hormone Menopause Oophorectomy Ovaries Research Surgery UK Biobank
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