Early pregnancy glycemia predicts postpartum diabetes BloodSugar Diabetes Glucose Pregnancy HbA1c DenverHealthMed CUBoulder
By Dr. Liji Thomas, MDSep 28 2022Reviewed by Benedette Cuffari, M.Sc. Research has long established the occurrence of diabetes mellitus in pregnancy, whether new-onset in the form of gestational DM or pre-existing, as a risk factor for future DM diagnosis.
Introduction The American College of Obstetricians and Gynecologists recommends pregnancy screening for DM using an initial glucose challenge test followed by an oral glucose tolerance test if GCT results are abnormal. However, this approach fails to distinguish between those with GDM and pre-existing DM or prediabetes.
HbA1C levels exceeded the diabetic threshold at the first visit and were classified as pre-existing DM. For the current study, the diagnosis was validated if the first DM test during the next three years postpartum was positive for the condition. Of the 65 women with an early normal HbA1C, only one later tested positive for DM postpartum with a negative predictive value of 99%. However, about one-third of these women later developed postpartum prediabetes.
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