Erenumab was more effective than oral preventive medications in reducing migraine days with better patient adherence and satisfaction.
Earlier treatment with erenumab was associated with significantly better migraine prevention than that with nonspecific oral migraine preventive medications in patients with resistant episodic migraine. Based on this research, the investigators suggest clinicians should start erenumab early and not prolong use of OMPMs.
Primary endpoint was the proportion of patients who completed 12 months of the initially assigned treatment and experiencing a reduction of ≥ 50% from baseline in MMDs at the end of the year. Secondary endpoints included cumulative mean change from baseline in MMDs during the treatment period and the proportion of responders at month 12 for patients taking the initially assigned treatment.At month 12, patients receiving erenumab were six times more likely to report a ≥ 50% reduction in MMDs than those receiving OMPMs or discontinued treatment due to adverse events .
Incidence of treatment-emergent adverse events was similar between the treatment arms until the researchers adjusted for exposure to treatment, which revealed a roughly 30% lower exposure-adjusted rate in the erenumab group."Earlier initiation of erenumab may ultimately lead to fewer patients discontinuing or switching medication in a real-world clinical practice," the authors wrote.
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