Effect of COVID-19 mRNA vaccination on COVID-19 severity during Omicron BA.4 and BA.5 predominance periods medrxivpreprint CDCgov COVID19 mRNA Omicron Vaccination
By Neha MathurOct 10 2022Reviewed by Aimee Molineux In a recent study posted to the medRxiv* preprint server, researchers estimated the association of first-generation messenger ribonucleic acid vaccines with coronavirus disease 2019 -related medical encounters.
Since then, several more Omicron sub-variants have emerged, including BA.4 and BA.5, which had even greater immune escape potential than BA.1. From June 2022, BA.4 and BA.5 sublineages have become predominant in the US. As new circulating variants of concern emerge, ongoing VE monitoring has become critical for informing public health strategies and policies.
About the study In the present study, researchers retrieved data from the U.S. Centers for Disease Control and Prevention run VISION Network to perform serial assessments of COVID-19 VE in the emergency department /urgent care . The VISION network covers 268 hospitals, 292 emergency departments, and 140 urgent care clinics across 10 US states.
The researchers used the multivariable logistic regression to estimate the association between symptomatic laboratory-confirmed SARS-CoV-2 infection at an ED/UC encounter or hospitalization and vaccination status. They used the same model to compare the odds of prior receipt of 2, 3, and 4 vaccine doses vs. unvaccinated status in SARS-CoV-2–positive cases vs. SARS-CoV-2–negative controls.
Regarding epidemiology, cases hospitalized during the BA.4/BA.5 predominance period tended to be less severe than the earlier BA.1 period , although they were eight years older on average.
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