A study published in Lipids in Health and Disease finds that in middle-aged and older Japanese adults, ingestion of 300 mg/day egg yolk choline improves verbal memory, a part of cognitive function. Large-scale studies are warranted.
The supplements used in this study were soft capsule-shaped and were manufactured by Aliment Industry Co., Ltd. . In the previous study, it was reported that 300 mg of egg yolk choline per day maintained verbal memory, one of the typical cognitive functions []. Therefore, egg yolk oil, including 300 mg of egg yolk choline, was included in supplements for the choline group, and lecithin-free egg yolk oil was included in supplements for the placebo group.
shows the nutrient composition of each supplement. Participants consumed seven capsules per day after breakfast. Egg yolk choline is presented in PC equivalent and in theoretical value. The choline value is calculated from egg yolk choline.As the primary endpoint, the Cognitrax test , a computer-based cognitive test with a Japanese version developed by CNS Vital Signs, LLC. [], was administered. Cognitrax comprised 7 test items , and the results were shown as 11 domain scores .
The test results are presented as the mean ± standard error of the amount of change. The statistical significance level was set at<0.05. Statistical analysis was performed using the computer software IBM Statistical Package for the Social Sciences version 28.0 ). The change amounts of Cognitrax, TMT-A and B, and plasma choline levels were compared between the choline and placebo groups at different time points by a Student’s-test.
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