A study published in BMC Complimentary Medicine and Therapies finds that topical 0.1% cannabidiol reduces ulcer size and accelerates healing without any side effects. Thus, it may be appropriate for canker sores patients.
The safety of CBD has been demonstrated in animal and human studies. It has a low adverse effect profile, including when chronically used []. However, there are some reports of sedation and somnolence with CBD use. Prescribing CBD with other sedative drugs, such as opioids and benzodiazepines, can cause severe respiratory depression.
]. Scoring was performed again 24 h later. The subjects and examiner were blinded to which chambers contained CBD. The examiner did the relabeling for statistical analysis.To assess the local and systemic side effects of CBD oral paste after applying it on healthy oral mucosa, 50 healthy subjects were recruited to participate in this study. The subjects were instructed to apply CBD over their lower labial mucosa with a provided calibrated spoon 3 times/day after meals for 7 d.
]. The final estimated total sample size was 60. To compensate for error or loss of subjects during follow-up, based on an anticipated drop-out rate of 15%, a total sample size of 72 subjects were recruited.
None of the subjects experienced or reported an obvious adverse reaction on their oral mucosa. Furthermore, no anaphylactic reactions were observed in the respiratory or circulatory system and no signs of liver dysfunction were reported . The subjects’ vital signs and blood parameters were stable before and after the 7-day CBD intervention .Seventy-two patients were enrolled in this study during September 2021–April 2022. Twenty-four subjects were assigned to each intervention.
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