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A new study reveals in greater detail how one of those defenses occurs: with rapid molecular changes to a membrane protein called
On the flip side, understanding how the process of egg coat hardening works – and when it goes awry – could lead to new insights about female infertility and also seed ideas for non-hormonal contraceptives that could temporarily interfere with the formation of the egg coat.Before fertilization, ZP2 proteins cling to the egg's outer coat, and when a sperm enters, those proteins are snipped into pieces.
Scientists just didn't know what those structural changes specifically were, so the model of ZP2 proteins had remained the same for In turn, this makes the zona pellucida more rigid, stopping any more than one sperm from worming its way into the egg.
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