Medications to treat malignant hyperthermia and pediatric hypotension have been recommended for marketing authorization by the European Medicines Agency.
Malignant hyperthermia is a rare disorder in which skeletal muscles are overstimulated and unable to relax. Sudden onset can be triggered by, or occasionally by stresses such as vigorous exercise or heat. Malignant hyperthermia can be life-threatening because it causes a rapid rise in body temperature and/or metabolic acidosis.
Agilus contains the same active substances as Dantrolen IV 20 mg but will be available in a 120-mg powder for solution for injection. In the formulation of Agilus, theand sodium hydroxide have been replaced with hydroxypropyl-beta-cyclodextrin and Macrogol 3350 to shorten the preparation time and improve ease of use.
Agilus is indicated for the treatment of malignant hyperthermia in adults and children of all ages in combination with adequate support measures. The most common side effect is muscle weakness.Dopamine hydrochloride works by stimulating adrenergic receptors of the sympathetic nervous system, increasing systemic vascular resistance and blood pressure in a dose ‑ dependent manner.
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