Myasthenia gravis (MG) is a chronic autoimmune disorder in which antibodies block communication between nerves and muscle, resulting in weakness of the skeletal muscles.
Emory Health SciencesOct 21 2024 Myasthenia gravis is a chronic autoimmune disorder in which antibodies block communication between nerves and muscle, resulting in weakness of the skeletal muscles. It can cause double vision, difficulty swallowing, and, occasionally, serious breathing difficulties, among other symptoms.
Human antibodies, although critically important for mounting an immune response to pathogens and fighting disease, sometimes cause disease themselves – including autoimmune diseases. The enzymes we discovered can modify antibodies in such a way that they no longer cause disease." A more effective treatment option The newly discovered enzyme was used to treat a number of different IgG-mediated pathologies in mice and found to be extremely effective. Compared to drugs currently on the market to treat MG, the new enzyme was found to be much more effective in reducing symptoms, and at a much lower dose – 4,000 times less of the enzyme was needed to create the same biological effect.
Biochemistry Breathing Cell Chronic Efficacy Enzyme Medicine Muscle Myasthenia Gravis Research Swallowing
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