Reducing the release of the 'hunger hormone' ghrelin through ablation of the gastric fundus lining shows promise for weight loss, a small study found.
Ablation of the gastric fundus to reduce production of the"hunger hormone" ghrelin resulted in decreased appetite and significant weight loss among participants in a small first-in-human trial.
Researchers targeted the gastric fundus because its mucosal lining contains 80%-90% of the cells that produce ghrelin. When a person diets and/or loses weight, ghrelin levels increase, making the person hungrier and preventing sustained weight loss, McGowan said. No serious adverse events were reported. Participants described gas pressure, mild nausea, and cramping, all of which lasted 1-3 days, he said.
Obesity Obese Fundus Bariatric Surgery Obesity Surgery Weight Loss Surgery Weight Loss Ablation Stomach Pain Management Acute Pain Quality Of Life QOL Health Related Quality Of Life Health-Related Quality Of Life HRQOL General Anesthesia Practice Management Revenue Endoscopy
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