Corrupt endothelialcells found to protect blood cancer cells from chemotherapy WeillCornell
We generated 22 T-ALL PDX models to identify T-ALL liabilities and investigate the interplay between leukaemia and endothelial cells.
We identified active compounds, some of which were effective in-vivo. Interacting EC and T-ALL underwent reciprocal transcriptomic changes.T-cell acute lymphoblastic leukemia is an aggressive and often incurable disease. To uncover therapeutic vulnerabilities, we first developed T-ALL patient-derived tumor-xenografts and exposed PDX cells to a library of 433 clinical-stage compounds. We identified 39 broadly active compounds with anti-leukemia activity.
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