Within each of us lies an army of cells whose topmost duty is protecting against external pathogens and internal threats such as proliferating cancer cells.
Texas A&M UniversityAug 14 2024 Yet, immune cells can sometimes erroneously attack the body, causing autoimmune diseases like type 1 diabetes .
"We are excited that the NIH will be supporting us in our research in this area, which has implications for not just type 1 diabetes but also other autoimmune diseases," said Dr. Roland Kaunas, associate professor in the biomedical engineering department and a grant award recipient. "Mesenchymal stem cells are valuable as a therapy because they can dampen the immune response, but as of now, they are not FDA approved," said Kaunas. "This is a strong motivation for developing cell-free versions of stem cell therapies that could represent a lower hurdle to getting approval by the FDA."
Related StoriesNow, Lee and Kaunas are investigating if extracellular vesicles can be engineered to deliver additional immune-suppressing proteins to more effectively prevent the immune system's destruction of insulin-producing beta-cells. Then, they plan to demonstrate whether the engineered extracellular vesicles can prevent or even reverse the onset of type 1 diabetes.
Therapeutics Cancer Cell Immune System Insulin Mesenchymal Stem Cells Pancreas Preclinical Research Stem Cells Type 1 Diabetes
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