Neuroscientists have used a nanosized sensor to record spinal cord neurons in free-moving mice, a feat that could lead to the development of better treatments for spinal cord disease and injury.
Implantable technologies have significantly improved our ability to study and even modulate the activity of neurons in the brain, but neurons in the spinal cord are harder to study in action.
According to the study, the sensor was used to record neuronal activity in the spinal cord of freely moving mice for prolonged periods and with great resolution, even tracking the same neuron over multiple days. "This flexibility gives it the stability and biocompatibility we need to safely record spinal neurons during spinal cord movements," said Chong Xie, an associate professor of electrical and computer engineering and bioengineering and a corresponding author of the study."With spinalNET, we were able to get low-noise signals from hundreds of neurons."
The researchers said they hope to help unravel some of this complexity in future research, tackling questions such as the difference between how spinal neurons process reflex motion -- getting startled, for instance -- versus volitional action.
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