This article explores the critical role of Nuclear Magnetic Resonance (NMR) spectroscopy inpharmaceutical development.
Sponsored Content by Oxford Instruments NMR Reviewed by Maria OsipovaAug 21 2024 Process development is key to identifying the optimal parameters used for synthesis, manufacturing, and stability testing. It is also key to generating the data required for the filing processes of many pharmaceutical regulatory bodies.
Figure 1. One-dimensional 1H stacked spectra of a reaction mixture before and after reaction. Image Credit: Oxford Instruments NMR For example, fluorine is a high-sensitivity NMR active nucleus frequently found to be more powerful for reaction monitoring than the more widely used hydrogen. Thanks to the less complex fluorine NMR spectra and the wider chemical shift dispersion, straightforward resolution of reactant and product signals is possible.
Knowing the identities of reactants and products is essential in drug development and production, as is understanding the reaction process and kinetics. Figure 3. Stacked series of one-dimensional 1H NMR spectra acquired during online monitoring of the reduction of 3-nitrobenzaldehyde to 3-nitrobenzyl alcohol. Image Credit: Oxford Instruments NMR
NMR Optimizing Synthesis Processes Real-Time Reaction Monitoring
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