Explore how dynamic vapor sorption (DVS) technology is revolutionizing pharmaceutical development by improving material characterization, optimizing formulation processes, and enhancing product stability.
Sponsored Content by Surface Measurement Systems LtdReviewed by Olivia FrostOct 28 2024 Dynamic Vapor Sorption is a potent analytical technique used in the pharmaceutical industry to determine how much vapor a sample absorbs or desorbed under regulated temperature and humidity conditions.
After establishing a baseline, the system was set to a low partial pressure environment before initiating crystallization at 30 % p/p0. To induce a phase change, ethanol concentration was then increased to 85 % p/p0, leading to the formation of a crystalline material. Analysis of drug excipient moisture interactions Moisture sorption isotherms, which illustrate the equilibrium moisture content of a material across various relative humidity levels, are crucial for understanding and predicting the behavior of pharmaceuticals under different environmental conditions.
Lovastatin, being highly hydrophobic, shows minimal mass change between 0 and 95 % RH. In contrast, HPC and MCC, which are significantly more hydrophilic, exhibit more pronounced moisture absorption. The experiment begins with a stable baseline and then gradually increases the relative humidity by 10 % per hour until reaching 90 %. Initially, moisture adsorbs on the surface of the material. As the relative humidity rises, lactose undergoes a glass transition, causing moisture to penetrate the bulk of the material. This increased moisture uptake enhances molecular mobility, leading to recrystallization once the relative humidity exceeds 80 %.
Packaging materials Packaging materials protect food products from external conditions, and their capacity to interact with moisture has a substantial impact on shelf life and quality. Improvements in quality control and assurance DVS is a significant instrument for quality control in pharmaceutical manufacturing. It ensures that materials meet the moisture content parameters required to maintain product quality and regulatory compliance. Regular usage of DVS in quality assurance processes ensures that each batch of goods meets the desired criteria.
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