Complete your Xbox Splinter Cell collection today — every game in the series is currently featured in the latest Xbox sale!
remake, for instance — but it's certainly a rarer occurrence when it comes to older titles. This week, though, Splinter Cell fans can pick up all four original Xbox games as well as the three Xbox 360 games at pretty decent discounts, with a couple of them reduced to new low prices.While we await more news on Ubisoft's upcoming Splinter Cell remake, we can always dive back into some of Sam Fisher's previous outings to get our stealth fix.
These games are part of the Publisher Spotlight Series sale that runs until March 27th, so you've got just shy of two weeks to grab them if you're looking to round out your digital Splinter Cell collection.Tom Clancy's Splinter Cell® introduces a new type of game to the lineup: a third-person stealth action game with cyber-terrorism, shadow agencies and covert operations on the menu.
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scEvoNet: a gradient boosting-based method for prediction of cell state evolution - BMC BioinformaticsBackground Exploring the function or the developmental history of cells in various organisms provides insights into a given cell type's core molecular characteristics and putative evolutionary mechanisms. Numerous computational methods now exist for analyzing single-cell data and identifying cell states. These methods mostly rely on the expression of genes considered as markers for a given cell state. Yet, there is a lack of scRNA-seq computational tools to study the evolution of cell states, particularly how cell states change their molecular profiles. This can include novel gene activation or the novel deployment of programs already existing in other cell types, known as co-option. Results Here we present scEvoNet, a Python tool for predicting cell type evolution in cross-species or cancer-related scRNA-seq datasets. ScEvoNet builds the confusion matrix of cell states and a bipartite network connecting genes and cell states. It allows a user to obtain a set of genes shared by the characteristic signature of two cell states even between distantly-related datasets. These genes can be used as indicators of either evolutionary divergence or co-option occurring during organism or tumor evolution. Our results on cancer and developmental datasets indicate that scEvoNet is a helpful tool for the initial screening of such genes as well as for measuring cell state similarities. Conclusion The scEvoNet package is implemented in Python and is freely available from https://github.com/monsoro/scEvoNet . Utilizing this framework and exploring the continuum of transcriptome states between developmental stages and species will help explain cell state dynamics.
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Single-cell transcriptomic atlas-guided development of CAR-T cells for the treatment of acute myeloid leukemia - Nature BiotechnologyNew targets for CAR-Tcelltherapy against acutemyeloidleukemia through AI-assisted analysis NatureBiotech
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What games could leave Xbox Game Pass in April 2023?April is fast approaching, and to help you get an idea of what games to focus on before they leave the service next month, we've produced a list of titles that could drop out of Game Pass in April.
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Gut microbiome can play key role in response to CAR-T cell cancer immunotherapyScientists from German Cancer Research Center (DKFZ), together with colleagues from Germany, Israel, and the U.S., have found that the gut microbiome may modulate the efficacy of CAR-T cellular immunotherapy CAR-T cells in patients with B cell lymphomas. Individualized microbiome information retrieved from patients' gut microbiomes prior to initiation of CAR T therapy could accurately predict their subsequent responsiveness to therapy, but only in the condition that these patients were not pre-treated with broad spectrum antibiotics.
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Popular Xbox games: March 13th, 2023Our latest TrueAchievements Gameplay Chart of popular Xbox games sees Wo Long: Fallen Dynasty making its way towards the top five, while Hogwarts Legacy falls down the top ten.
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A mystery ‘racing and flying’ game from EA has been added to the Xbox store | VGCEA could be set to reveal a new racing or flying game soon, after a mystery title was added to the Xbox store’s backend
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