Enzymes Discovered in Gut Bacteria Can Change a Donor's Blood Groups

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Enzymes Discovered in Gut Bacteria Can Change a Donor's Blood Groups
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When a life hangs in the balance, blood transfusions can help sustain a patient – but only if the donor's blood type is a match.that can, in lab studies, transform red blood cells into the universal type O with"remarkably high efficiencies" – improving on an idea hatched 40 years ago.

Immune systems that have never seen types A or B will attack and destroy these cells on sight if they receive them in a transfusion, whereas type O blood is far more . For unknown reasons, donor blood was sometimes still incompatible in recipients despite donor cells being stripped of nearly all their antigens.

"Here we report the discovery of remarkably efficient enzymes, not only against A and B antigens but also against their extensions," Mathias Jensen and Linn Stenfelt, two bioengineers at the Technical University of Denmark,Importantly, for potential clinical use, the enzymes were incubated with high concentrations of red blood cells, at room temperature and for only 30 minutes – improving on the longer processing and less efficient conditions of previous candidates.

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