Research in biomedical laboratories has been changing significantly in recent years, to the point that test tubes have given way to computers on many occasions.
Josep Carreras Leukaemia Research InstituteNov 27 2024 In this context, many discoveries now begin with detailed studies of molecular and cellular databases, followed by the validation and expansion of these findings through experiments conducted in the classic white lab coat, and finally by the translation of this knowledge into clinical settings, thanks to the white-coated professionals in hospitals.
Dr. Esteller explains that the team has obtained "the epigenetic profiles of the most extensive collection of cultured cells derived from transformed cells in the bloodstream, bone marrow, and lymph nodes up to date, examining in them over 800,000 sites of genome modification due to DNA methylation". This includes both human and mouse malignant samples, making the patterns obtained potentially useful to basic, applied, and clinical researchers.
Besides the pure characterisation of the malignant cells' epigenome, the study also cross-referenced the epigenetic data with information on the sensitivity of over 300 drugs, so "now, a separate algorithm can predict which epigenetic lesion is associated with sensitivity or resistance to a medication", an important milestone for clinical research according to Dr. Esteller.
Malignant Cancer Cell DNA DNA Methylation Leukemia Research Translation
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