The role that Epstein-Barr Virus (EBV) plays in the development of Multiple Sclerosis may be caused a higher level of cross-reactivity, where the body's immune system binds to the wrong target, than previously thought.
The common virus' link with Multiple Sclerosis is likely to be caused by greater amounts of immune system 'misdirection' than previously thoughtThe role that Epstein-Barr Virus plays in the development of Multiple Sclerosis may be caused a higher level of cross-reactivity, where the body's immune system binds to the wrong target, than previously thought.
While previous studies have shown that antibody responses to one EBV protein -- EBNA1 -- also recognise a small number of proteins of the central nervous system, this study found that T-cells, another important part of the immune system, that target viral proteins can also recognise brain proteins. "The discovery of the link between Epstein-Barr Virus and Multiple Sclerosis has huge implications for our understanding of autoimmune disease, but we are still beginning to reveal the mechanisms that are involved. Our latest study shows that following Epstein-Barr virus infection there is a great deal more immune system misdirection, or cross-reactivity, than previously thought."
"Our detection of cross-reactive T-cells in healthy individuals suggests that it may be the ability of these cells to access the brain that is important in MS.
Multiple Sclerosis Research Viruses Lymphoma Multiple Sclerosis Disorders And Syndromes Huntington's Disease Brain-Computer Interfaces
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