Risk of autism associated with when and where forebears lived
The study has several strengths, most relating to the high data integrity and the richness of the records, allowing investigators to place individuals in pedigrees, and throughout space and time. The dataset allows us to link family members over space and time at different vulnerable developmental windows and has been key to identifying space-time clustering. The rich location data within the records provide sufficient information to include thousands of records.
Additionally, we used only clinically diagnosed ASD case children to create our family pedigrees. While keeping our ASD cases defined by clinical diagnosis, we used a broad statewide dataset, as opposed to limiting the study to a specific county or regional jurisdiction. This decision was made to ensure the study included both rural and urban residential locations over space and time.
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