Researchers explore the impact of exercise on the short-term regulation of insulin pathways in brain circuits.
By Dr. Liji Thomas, MDReviewed by Benedette Cuffari, M.Sc.Jan 28 2025 Rutgers study reveals that exercise activates insulin-related brain cells, potentially improving cognition and offering new strategies to prevent dementia
Reduced insulin trafficking in the brain is associated with aging and prediabetes, which can reduce neuronal insulin signaling and/or lead to insulin resistance. In fact, insulin sensitivity is considered a key feature of Alzheimer’s disease and related dementia . About the study Prediabetes is characterized by fasting blood glucose levels between 100 and 125 mg/dL, two-hour postprandial glucose levels within the range of 140 to 199 mg/dL, and/or glycosylated hemoglobin levels between 5.7-6.4%. All study participants were diagnosed with prediabetes, as demonstrated by a 75 g glucose tolerance test assessed according to the American Diabetes Association criteria.
Immediately before OGTT and one hour from the start, nEV levels were measured to determine nEV-associated insulin signaling protein and pro-BDNF levels. Differences in protein levels at these time points reflected the stimulation of insulin release by the OGTT.
Dementia Exercise Insulin Prediabetes Aging Blood Cell Cognitive Function Cortex Fasting Glucose Hormone Hypothalamus Insulin Resistance Muscle Neurons Pathophysiology Protein
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