Identifying and analyzing volatile organic compounds in exhaled breath of patients with malignant pleural mesothelioma showed promise as a screening method for MPM, according to research presented today at the International Association for the Study of Lung Cancer (IASLC) 2023 World Conference on Lung Cancer in Singapore.
Identifying and analyzing volatile organic compounds in exhaled breath of patients with malignant pleural mesothelioma showed promise as a screening method for MPM, according to research presented today at the International Association for the Study of Lung Cancer 2023 WorldMalignant pleural mesothelioma is a challenging disease with limited treatment options and a poor prognosis.
Kevin Lamote, Ph.D., from the University of Antwerp, Belgium, and colleagues conducted a study aimed to investigate whether exhaled breath analysis could differentiate treatment responders from non-responders and, if successful, predict treatment outcomes earlier using VOCs as predictive biomarkers.
Dr. Lamote and his team examined 13 patients with MPM and subjected them to a CT scan before and every three months after treatment, with treatment responses scored as stable or progressive based on mRECIST criteria. Breath and background samples were collected from the patients at each time point using multi-capillary column-ion mobility spectrometry to characterize VOCs.
The study demonstrated an 89% accuracy in distinguishing between SD and PD patients during follow-up. Equally promising, theachieved the same level of accuracy at baseline in predicting treatment outcomes. Notably, there were no significant differences in treatment approaches between SD and PD patients, suggesting that the selected VOCs may be involved in general mechanisms or correlated with the
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