Ultrasound imaging offers a valuable and noninvasive way to find and monitor cancerous tumors. However, much of the most crucial information about a cancer, such as specific cell types and mutations, cannot be learned from imaging and requires invasive and damaging biopsies.
May 14 2024Acoustical Society of America One research group developed a way to employ ultrasound to extract this genetic information in a gentler way.
Ultrasound, at exposure levels higher than is used for imaging, can create tiny pores in cell membranes, which safely reseal. This process is known as sonoporation. The pores formed due to sonoporation were previously used to get drugs into cells and tissues. In our case, we care about releasing the contents of cells for diagnostics." The ultrasound releases biomarkers from the cells into the bloodstream, increasing their concentration to a level high enough for detection.
Not only was this approach successful at detecting biomarkers, but it also boasts a lower price compared to conventional testing. The team also demonstrated the potential for applying intense ultrasound to liquefy small volumes of tissue for biomarker detection. The liquified tissue can be retrieved from blood samples or through fine-needle syringes, a much more comfortable option compared to the damaging core-needle alternative.
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