This study aims to investigate the impact of different vascularization strategies on the nervous system and vasculature in human cerebral organoids. Cerebral organoids lack functional vasculature, which hinders long-term culture and the study of neurovascular interactions. Several strategies for vascularization have been reported, but their generalizability and variability remain unclear. This study aims to provide a comprehensive characterization and comparison of these strategies.
Cerebral organoids are three-dimensional in vitro cultured brains that mimic the function and structure of the human brain . One of the major challenges for cerebral organoids is the lack of functional vasculature. Without perfusable vessels, oxygen and nutrient supplies may be insufficient for long-term culture, hindering the investigation of the neurovascular interactions. Recently, several strategies for the vascularization of human cerebral organoids have been reported.
However, the generalizable trends and variability among different strategies are unclear due to the lack of a comprehensive characterization and comparison of these vascularization strategies. In this study, we aimed to explore the effect of different vascularization strategies on the nervous system and vasculature in human cerebral organoids
Cerebral Organoids Vascularization Strategies Neurovascular Interactions Human Brain Vasculature
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