Thyroid hormone plays a key role in regulating a range of physiologic functions, including metabolism, temperature, heart rate, and growth. It accomplishes this impressive array of activities by interacting with almost every organ system in the body.
Harvard Medical School Aug 23 2024 Yet despite a long history of research on how thyroid hormone influences different organs, its effects on arguably the most crucial organ -; the brain -; have remained shrouded in mystery.
Daniel Hochbaum, Study Lead Author and Research Fellow, Neurobiology, Blavatnik Institute, Harvard Medical School "Why thyroid hormone changes behavior has been something that's puzzled me ever since medical school," said Sabatini, who is also director of the Kempner Institute for the Study of Natural and Artificial Intelligence at Harvard University and senior author on the new study. "It was not clear why this hormone should even enter the brain at all.
Moreover, when researchers induced higher levels of thyroid hormone in the cortex, mice became more willing to explore the environment and take risks. "We think that thyroid hormone acts directly on brain circuits to coordinate exploratory behaviors with metabolic rate," he added. "It's syncing up your brain and body for the current environment."
Thyroid Bipolar Disorder Brain Cell Cortex Depression Heart Heart Rate Hypothalamus Medical School Metabolism Pituitary Gland Receptor Research
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