Study links phthalate exposure during pregnancy to a higher risk of hypertensive disorders, including preeclampsia. Findings highlight the need for preventive strategies to reduce this risk.
By Dr. Priyom Bose, Ph.D.Jun 11 2024Reviewed by Benedette Cuffari, M.Sc. A recent Environment International study investigates the association between pregnancy phthalate exposure and the development of hypertensive disorders of pregnancy , such as preeclampsia/eclampsia .
Gestational hypertension and PE/E are characterized by high blood pressure during pregnancy, which significantly increases the risk of various complications, including intrauterine growth restriction, preterm birth, maternal pregnancy-related mortality, maternal organ damage, and cardiovascular diseases.
The widespread use of phthalates increases the likelihood of their exposure to pregnant women. Most available studies on phthalate exposure and PE or other HDP incidence have small sample sizes, which require further validation. For the current study, pregnant women from diverse geographical and sociodemographic backgrounds were selected. Individuals between 18 and 40 years of age during the delivery provided detailed data on prenatal measures of urinary phthalate exposure biomarkers, and PE, eclampsia, gestational hypertension, and singleton pregnancies were included in the study.
Conclusions A significantly higher risk of HDP, particularly PE/E, was associated with phthalate exposure during pregnancy. Thus, maternal exposure to several phthalates, both alone and in combination, could be associated with overall HDP and PE/E.
Blood Blood Pressure Child Health Eclampsia Food Genetic High Blood Pressure Intrauterine Growth Restriction Metabolites Mortality Phthalates Research
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