Announcing a new article publication for Cardiovascular Innovations and Applications journal. This study sought to determine the potential of extracellular vesicle (EV) microRNAs (miRNAs) to serve as early diagnostic biomarkers for AMI.
Compuscript LtdJan 17 2025 Announcing a new article publication for Cardiovascular Innovations and Applications journal. This study sought to determine the potential of extracellular vesicle microRNAs to serve as early diagnostic biomarkers for AMI.
Peripheral blood samples were collected from three patients with AMI and three healthy individuals, and serum EV total RNA was extracted. The miRNA differential expression profiles of serum EVs were obtained through next-generation sequencing combined with bioinformatics analysis. In patients with AMI, compared with controls without AMI, 15 differentially expressed miRNAs were identified. GO analysis predicted 842 target genes. Enrichment analysis revealed 639 genes involved in biological processes, 592 genes involved in molecular function, and 692 genes involved in cellular components. KEGG analysis indicated that the protein processing in the endoplasmic reticulum pathway, P53 pathway, and mRNA surveillance signaling pathway significantly correlated with AMI.
Fifteen significantly differentially expressed miRNAs in AMI were identified, whose target genes significantly correlated with protein processing in the endoplasmic reticulum pathway and the P53 pathway. These results provide a reference for use of EV miRNAs as early diagnostic biomarkers in patients with AMI.Journal reference:Chen, W., et al. .
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