The social media giant is under pressure after a sharp slowdown in its ads business last year.
Facebook owner Meta has started notifying staff who are losing jobs in the wave of 10,000 job cuts the social media company announced last month.Meta, which also owns Instagram and WhatsApp, has been under pressure since a sharp slowdown in its ads business last year.Some of the people affected by Meta's latest decisions wrote on social media saying they were looking for new roles.
The moves come as the corporate world is bracing for a wider economic slowdown, as higher borrowing costs start to slow business activity. The tech industry, where low borrowing costs had helped fuel investments and growth, has been hit particularly hard. More than 170,000 people in the industry have been laid off globally since the start of the year, according to announcements tracked by website layoffs.fyi, with big names such as Amazon and Google accounting for some of the largest actions.
Among the other announcements this week, online property firm Opendoor said it would reduce its workforce by roughly 560 jobs or 22%.
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Propofol and survival: an updated meta-analysis of randomized clinical trials - Critical CareBackground Propofol is one of the most widely used hypnotic agents in the world. Nonetheless, propofol might have detrimental effects on clinically relevant outcomes, possibly due to inhibition of other interventions' organ protective properties. We performed a systematic review and meta-analysis of randomized controlled trials to evaluate if propofol reduced survival compared to any other hypnotic agent in any clinical setting. Methods We searched eligible studies in PubMed, Google Scholar, and the Cochrane Register of Clinical Trials. The following inclusion criteria were used: random treatment allocation and comparison between propofol and any comparator in any clinical setting. The primary outcome was mortality at the longest follow-up available. We conducted a fixed-effects meta-analysis for the risk ratio (RR). Using this RR and 95% confidence interval, we estimated the probability of any harm (RR | 1) through Bayesian statistics. We registered this systematic review and meta-analysis in PROSPERO International Prospective Register of Systematic Reviews (CRD42022323143). Results We identified 252 randomized trials comprising 30,757 patients. Mortality was higher in the propofol group than in the comparator group (760/14,754 [5.2%] vs. 682/16,003 [4.3%]; RR = 1.10; 95% confidence interval, 1.01–1.20; p = 0.03; I2 = 0%; number needed to harm = 235), corresponding to a 98.4% probability of any increase in mortality. A statistically significant mortality increase in the propofol group was confirmed in subgroups of cardiac surgery, adult patients, volatile agent as comparator, large studies, and studies with low mortality in the comparator arm. Conclusions Propofol may reduce survival in perioperative and critically ill patients. This needs careful assessment of the risk versus benefit of propofol compared to other agents while planning for large, pragmatic multicentric randomized controlled trials to provide a definitive answer. Graphical Abstract
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