New study uncovers major cause of deadly heart arrhythmias johnshopkins
presents two examples of VT circuits in hybrid CT-MRI models with isthmuses consisting of both inFAT and scar., Example of two VT circuits from hybrid CT-MRI models with isthmuses consisting of both inFAT and scar. Arrows trace the VT circuit from the exit site to the common pathway. Dashed circles denote the location of the critical isthmus., Example of a VT circuit from an LGE-based heart model. The inFAT distribution, superimposed from CE-CT, is displayed in the right panel.
First, we examined whether the amount of inFAT or scar in the region encompassing the VT circuit in the hybrid CT-MRI heart models was associated with the volume of clinically measured pro-arrhythmic conduction abnormalities. Larger amounts of inFAT in regions that encompassed the VT circuits were associated with larger volumes of ablated tissue and DZs . In contrast, the amount of scar in these regions was not associated with the volume of ablated tissues or DZs .
Next, we evaluated the association between LGE-based heart model VTs and EAM data. In these LGE-based models, larger amounts of inFAT in the region encompassing the VT circuit were associated with a larger volumes of ablated tissue and DZs . The same relationship was not true for the amount of scar in the region encompassing the VT circuit and the volumes of ablated tissue or DZs .
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