Disrupted gut microbiomes in male mice increase their offspring’s risk of low birth weight, stunted growth and premature death
Decreasing the diversity and abundance of gut microbes in male mice increases their offspring’s risk of low birth weight, stunted growth and premature death. This suggests that a father’sThe rodents – along with another 12 male mice that had stopped the antibiotic treatment two months earlier and 26 control mice not given antibiotics at all – then mated with females. Together the groups produced more than 400 offspring.
Pups from mice with impaired gut microbiomes had a variety of health issues not found in those whose fathers had not taken antibiotics or stopped the medication weeks before conception. They had significantly lower birth weights and were 2.5 times more likely to have severely stunted growth at 2 weeks old. Roughly 17 per cent of these pups died within three months, while only 5 per cent of those fathered by the control-group mice did.How the gut microbiome exerts these effects is unclear.
It also indicates that paternal health may be important for pregnancy outcomes, since placental changes are related to pregnancy complications likein humans, says Hackett. But this is merely speculation, since research in mice does not necessarily apply to humans, he adds.
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