On June 14, 2024, the U.S. FDA approved AstraZeneca's Durvalumab (IMFINZI®) for primary advanced or recurrent endometrial cancer with mismatch repair deficiency. Endometrial cancer is the most prevalent gynecologic cancer, with an estimated 66,200 new U.S. cases in 2023.
From Sino Biological Inc.Aug 5 2024 On June 14, 2024, the U.S. FDA approved AstraZeneca's Durvalumab for primary advanced or recurrent endometrial cancer with mismatch repair deficiency. Endometrial cancer is the most prevalent gynecologic cancer, with an estimated 66,200 new U.S. cases in 2023. This approval demonstrates the effectiveness of immune checkpoint inhibitors, particularly targeting PD-L1 , a crucial factor in tumor immune evasion.
PD-L1, a type 1 transmembrane protein, is induced by inflammatory signals such as IFN-gamma and is found on both tumor and immune cells in the tumor microenvironment. It inhibits T cell activation and function by binding to PD-1 and CD80 receptors on T cells, reducing the immune response.
Endometrial Cancer PD-L1 Cell Cell Death Immune Response Immunotherapy Ligand Programmed Cell Death Protein Research Tumor
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