Finerenone reduced the composite of total first and recurrent heart failure (HF) events (hospitalizations for HF or urgent HF visits) and cardiovascular death in patients with HF and mildly reduced or preserved ejection fraction, according to an international clinical trial led by investigators from Brigham and Women's Hospital, a founding member...
Brigham and Women's Hospital Sep 2 2024 Finerenone reduced the composite of total first and recurrent heart failure events and cardiovascular death in patients with HF and mildly reduced or preserved ejection fraction, according to an international clinical trial led by investigators from Brigham and Women's Hospital , a founding member of the Mass General Brigham healthcare system.
We saw benefit regardless of the ejection fraction and even in patients who were on other approved therapies. This drug represents a new drug class that may become a pillar of therapy for this disease." Scott Solomon, MD, trial principal investigator and corresponding author, director of the Clinical Trials Outcomes Center at Mass General Brigham and the Edward D. Frohlich Distinguished Chair at Brigham and Women's Hospital
HF is the progressive decline in the heart's ability to fill with and pump blood. It affects over 60 million people worldwide. Approximately half of all people living with HF have mildly reduced or preserved left ventricular ejection fraction, a condition with limited treatment options. These findings suggest that the non-steroidal mineralocorticoid receptor antagonist finerenone could represent a new therapeutic option for patients.
The FINEARTS-HF trial, funded by Bayer, assigned 6,000 patients to receive either finerenone or placebo in addition to their existing therapies. The trial's limitations include few Black patients, although the percentage of Black patients was proportional to their regional population. "Our group continues to study novel therapies for heart failure," Solomon said. "There's huge residual risk in these patients and so more room for new therapies.
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