Research indicates first-generation antihistamines may elevate seizure risk in young children, highlighting the need for careful prescription practices.
By Pooja Toshniwal PahariaReviewed by Lily Ramsey, LLMAug 30 2024 In a recent study published in JAMA Network Open, researchers assessed associations between prescriptions of first-generation-type antihistamine drugs and seizures among children.
According to research, first-generation antihistamines can cause symptomatic seizures in adults while also influencing electroencephalographic activity and seizure thresholds. Generation 1 antihistamines enhance seizure susceptibility in rats, and genetically manipulated animal models support a relationship to epileptic seizures.
Exclusion criteria included children with missing birth records, those experiencing seizures at less than six months of age, and those who did not receive first-generation antihistamine prescriptions before the seizure event. The models compared generation 1 antihistamine prescriptions 15 days prior to the index date against two control periods, the first being 31 to 45 days preceding seizure occurrence and the second 61 to 75 days preceding the event.
Seizures were predominant among children six months to two years old and those aged between 25 months and six years . Fifteen days before seizure occurrence, 1,476 first-generation antihistamines were prescribed, 1,239 antihistamine prescriptions during the first control period, and 1,278 prescriptions during the second control period.
Children Drugs Seizure Antihistamines Blood Brain Cold Common Cold Histamine Research
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