Adult patients with newly diagnosed malignancy-associated hemophagocytic lymphohistiocytosis (mHLH) – a rare, aggressive hyperinflammatory condition – who were treated with the first-in-class monoclonal antibody, ELA026, experienced a 100% response rate and an improved survival rate at two months, according to researchers from The University of...
University of Texas M. D. Anderson Cancer CenterDec 9 2024 Adult patients with newly diagnosed malignancy-associated hemophagocytic lymphohistiocytosis – a rare, aggressive hyperinflammatory condition – who were treated with the first-in-class monoclonal antibody , ELA026, experienced a 100% response rate and an improved survival rate at two months, according to researchers from The University of Texas MD Anderson Cancer Center.
ELA026 works by targeting the SIRPα/b proteins found on myeloid cells and SIRPγ on T lymphocytes, leading to their depletion. In the global, open-label, single-arm trial, patients were treated with ELA026 for 12 weeks either intravenously or subcutaneously. Related StoriesBy week four, the response rate with ELA026 was 100% in the frontline setting, with two patients having a modified complete response and ten having a partial response. In mHLH patients treated in frontline settings, survival was 92% at two months, and the median overall survival had not yet been met at data cutoff.
Cancer Monoclonal Antibody Cell Hematology Hemophagocytic Lymphohistiocytosis Leukemia Lymphoma
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