Fit to beat diabetes: mendelian randomization study confirms the power of exercise NatureComms diabetes typetwodiabetes study research
By Pooja Toshniwal PahariaJul 5 2023Reviewed by Lily Ramsey, LLM In a recent study published in Nature Communications, researchers investigated the causality of the relationship between cardiorespiratory fitness and diabetes mellitus type 2 .
About the study In the present genome-wide association study , researchers examined causal associations between fitness and T2D using genetic risk scores for cardiorespiratory fitness as variables in Mendelian randomization . Logistic regression modeling was performed to determine the odds ratios for incident T2D according to fitness level in the UKBB, adjusting for age, sex, ethnicity, hypertension, anti-hypertensive medications, smoking, employment, area deprivation index, adiposity, history of stroke, heart failure, heart disease, atrial fibrillation, chronic obstructive pulmonary disease, or cancer, and intake of alcohol, meat, oily fish, fruits, and vegetables.
The findings were validated in the Fenland study cohort of 10,707 individuals. Further, the team explored the associations between genomically estimated cardiorespiratory fitness and serological proteins and conducted bioinformatic tests to provide insights into the underlying biological mechanisms. After adjusting for age, gender, adiposity, and other possible confounders, every one ml O2 per minute per kg of fat-free mass increase in fitness was related to a 3.0% decreased chance of developing T2D.
The team found a statistically significant. Bonferroni-corrected relationship between genetically estimated fitness and fasting insulin levels, but not for other parameters.
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