Frequent use of antibiotics may heighten the risk of inflammatory bowel disease—Crohn's disease and ulcerative colitis—among adults over 40, suggests research published online in the journal Gut.
To explore this further, the researchers drew on national medical data from 2000 to 2018 for Danish citizens aged 10 upwards who hadn't been diagnosed with IBD. They specifically wanted to know if the timing and dose of antibiotic might be important for the development of IBD, and whether this varied by IBD and antibiotic type.
The risks were slightly higher for Crohn's disease than they were for ulcerative colitis: 40% among 10-40 year-olds; 62% among 40-60 year-olds; and 51% among the over 60s. Timing also seemed to be influential, with the highest risk for IBD occurring 1-2 years after antibiotic exposure, with each subsequent year thereafter associated with a lowering in risk.
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