A team of researchers from Brazil constructed a lentivirus vector with expression specific for mammary glands and carrying the gene for human insulin.
By Dr. Chinta SidharthanMar 21 2024Reviewed by Lily Ramsey, LLM In a recent study published in the Biotechnology Journal, a team of researchers from Brazil constructed a lentivirus vector with expression specific for mammary glands and carrying the gene for human insulin.
Type 1 diabetes is due to insulin deficiency, which is most often autoimmune in nature and caused by the destruction of the β-cells in the islets of Langerhans in the pancreas. Type 2 diabetes is due to insulin resistance and its subsequent impact on insulin secretion by the pancreatic β-cells. They then used mass spectrometry and Western blotting techniques to evaluate the human proinsulin production by this transgenic cow.
An in vitro screening process ensures that only those cells that have successfully been transduced or transfected by the vector are used for the nucleus transfer. To evaluate the proinsulin expression in milk produced by this transgenic cow, it was hormonally induced to lactate, and the collected milk was analyzed using Western blotting analysis and mass spectrometry.
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