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Why Eli Lilly's plan to disrupt the traditional doctor-patient relationship makes us nervous.

Medical student, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PennsylvaniaAssistant Professor of Emergency Medicine, Lenox Hill Hospital, Northwell Health, New York, NYProfessor of Anesthesiology, Surgery, Neurology, and Neurosurgery, University of Rochester, Rochester, New York; Professor of Internal Medicine Mercer School of Medicine, Macon, Georgia-like peptide 1 receptor agonist akin to Mounjaro, Ozempic, and Wegovy — will be prescribed by independent telehealth...

On the surface, this design appears promising. Wait times for doctor's appointments will fall. Patients can order drugs from the comfort of their home. Everyone benefits. Or do they? Adding to these parallels, once a patient begins a GLP-1 medication such as Zepbound, stopping treatment will probably lead to regaining lost weight, serving as negative reinforcement. Hence, patients may decide never to discontinue these medications.

Furthermore, the lack of a regular physician to monitor patients introduces uncertainty in safety and continuity of care. These are important tenets in protecting patients, especially patients who are not diabetic and desire a quick fix. We have already seen a huge, arguably unrestrained, rise in prescriptions of GLP-1 RAs for weight loss — up to aexist — namely, serious gastrointestinal side effects and low blood glucose in nondiabetic persons — that an astute physician must consider.

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