Fresh insights into how glucose drives tuberculosis vaccine responses offer hope for improved efficacy tcddublin
). However, it will be important going forward to determine whether there are differences between the effects of live and killed BCG on DC metabolism.mDCs as potential targets to promote the protective immunity given by the BCG vaccine in tuberculosis infection. However, the disparate effects of glycolysis on bystander and infected CD1cmDCs function following exposure to mycobacteria highlight the complexity of this host response.
DT wrote the first draft of the manuscript, MO’S and DT wrote sections of the manuscript. All authors contributed to manuscript revision, read, and approved the submitted version.This work was supported by the Health Research Board, Ireland , the Faculty of Health Science, Trinity College Dublin, Dean’s Research Initiative Fund , and The Royal City of Dublin Hospital Trust .
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