Exercise has a direct role in fighting breastcancer tamu FrontPhysiol
), our results support the concept that the very act of locomotion has a direct therapeutic influence on breast cancer. Our work expands on that of others by using a hind limb perfusion preparation, where we can effectively remove other humoral factors, such as hormones or cytokines from other organs, that may also impact growing cancers, and administer that perfusate directly to the cancer cells.
In summary, we demonstrate that the protective benefits of exercise against breast cancer can be attributed, at least in part, to myokines released by contracting skeletal muscle, independent of any hormonal or whole-body effects of regular physical activity. These myokines suppressed cancer growth independent of whether they were derived from the muscles of a sedentary or active animal, indicating that the release of anti-cancer myokines is an inherent property of muscular contraction.
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