A scientific team supported by the National Institutes of Health (NIH) unveiled the first complete map of the neural connections of the common fruit fly brain. The map provides a wiring diagram, known as a connectome, and is the largest and most complete connectome of an adult animal ever created.
NIH/National Institute of Mental Health Oct 3 2024 A scientific team supported by the National Institutes of Health unveiled the first complete map of the neural connections of the common fruit fly brain. The map provides a wiring diagram, known as a connectome, and is the largest and most complete connectome of an adult animal ever created.
The diminutive fruit fly is surprisingly sophisticated and has long served as a powerful model for understanding the biological underpinnings of behavior. This milestone not only provides researchers a new set of tools for understanding how the circuits in the brain drive behavior but importantly serves as a forerunner to ongoing BRAIN-funded efforts to map the connections of larger mammalian and human brains.
In a companion paper, the researchers provided an annotation of the fly connectome, detailing cell types, cell classes, and more. It includes information critical for researchers and others who will use the connectome to advance our understanding of brain physiology and behavior. To create the fly connectome, researchers took electron microscope images of the complete fly brain that had been publicly released and used a computer program to automatically identify or "segment" the neurons in the images. The program is not foolproof, so the researchers created a computational system of tools that allowed a large online research community to look at the segments, proofread them for accuracy, and annotate cell types and classes in a community-driven manner.
Fruit Cell Chemicals Dopamine Health And Human Services Medical Research Mental Health Nervous System Neurons Ph Research Serotonin
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