A fungus discovered in the mouse stomach may hold a key to fungal evolution within the gastrointestinal tract, according to new research led by Weill Cornell Medicine investigators.
Weill Cornell Medicine Nov 27 2024 The finding suggests that preclinical studies until now have overlooked a major influencer of mouse physiology.
"For years we've been looking for a true fungal commensal in mice, but fungal populations in lab mice, as identified by analyzing fungal DNA, tend to be transient and vary greatly from colony to colony," said study senior author Dr.
"The presence or absence of this fungus should be taken into account in many types of mouse studies," said co-first author Dr. Yun Liao, a postdoctoral researcher in the Iliev laboratory. However, upon gastrointestinal mucus fluctuations caused by dietary changes or antibiotics, for example, the fungus becomes visible to the immune system by activating the production of a cytokine called IL-33. This cytokine, in turn, triggers what is known as a "type 2" immune response.
Stomach Cancer Cytokine Depression DNA Evolution Gastrointestinal Tract Immune Response Immunity Immunology Laboratory Medicine Mouse Model Physiology Preclinical Research Yeast
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