Aged garlic extract compound S1PC enhances communication between muscle cells and the brain, leading to improved muscle function and strength in animals, as per a recent study. This research suggests that S1PC, which activates liver kinase B1 (LKB1), can also travel through the bloodstream to reach the hypothalamus in the brain and improve muscle function.
How can garlic help maintain muscle mass? S-1-propenyl-L-cysteine, or S1PC, which is a compound found in aged garlic, seems to improve communication between mice’s fat cells and their brains.
That communication appears to improve muscle strength over time. This research found that SIPC activated liver kinase B1 , which leads to the secretion of extracellular nicotinamide phosphoribosyltransferase . And eNAMPT can also travel through the bloodstream to reach an area of the brain called the hypothalamus. Once there, it seems to improve muscle function.
This study showed that humans who were given aged garlic-derived S1PC had greater amounts of eNAMPT in their blood. And mice given the same compound saw reduced frailty across 31 health markers.
“We anticipate that S1PC is likely to have a broader anti-ageing effect that warrants detailed investigation,” said study author Dr Shin-ichiro Imai. : “During my clinical experience as a physical therapist, I was often frustrated to see older adults lose physical function and vitality simply because they had no specific disease requiring medical treatment. This gap in proactive care has driven my research.
“We hope our findings will help improve fitness and muscle strength in older individuals by the simple inclusion of a nutraceutical as part of the daily diet. ”“We have succeeded in expanding the current understanding of how different organs coordinate responses during ageing. Further research is needed to determine improvements in muscle function in humans and to evaluate the long-term effects of S1PC,”
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