A genetic predisposition to having lower insulin production and less healthy fat distribution are major causes of early-onset type 2 diabetes in British Asian people.
Queen Mary University of LondonNov 26 2024 According to new research from Queen Mary University of London, these genetic factors also lead to quicker development of health complications, earlier need for insulin treatment, and a weaker response to some medications.
The findings, published today in Nature Medicine, reinforce the need to understand how genetic variation across different population groups can influence the onset of diseases, treatment responses, and disease progression. Queen Mary researchers used data from the Genes & Health cohort, a community-based study of more than 60,000 British-Bangladeshi and British-Pakistani volunteers who have generously provided their DNA for genetic research.
In contrast to previous studies which included very few people of South Asian heritage, this research used partitioned polygenic scores to reveal the underlying genetic signatures causing type 2 diabetes specifically in people with South Asian ancestry.
We don't yet know whether genetic tools will be needed to deliver precision diabetes medicine in south Asian populations, or whether we can better and more widely use existing laboratory tests such as C-peptide which can be measured in a simple blood test. Genes & Health will contribute to future efforts to ensure that precision medicine approaches are developed and bring real benefits to south Asian communities living with, and at risk of, type 2 diabetes.
Genetic Type 2 Diabetes Body Mass Index Charity Dentistry DNA Genes Genetic Information Gestational Diabetes Healthcare Insulin Medicine Research
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