Breast cancer stem cells have specific molecular profiles that differ according to their phenotypes, which could affect patients’ prognosis and outcome, finds a study published in Cancer Cell International.
Therefore, the aim of the current study is to characterize the BCSCs by genetic profiling of different BCSCs phenotypic subsets, and determination of their related genetic pathways. This will allow us to accurately define the possible impact of BCSCs on the development and progression of the BC, as well as their contribution to patients' response to treatment, outcomes, and survival rates. Hence it will open a new avenue for potential targeted therapy in BC patients.
Fresh tumor samples were obtained from the operation theatre in a sterile, 50 ml plastic Falcon tube containing 10 ml of Dulbecco’s modified Eagle’s medium . The samples were transferred immediately to the tissue culture lab for processing. A section of the tumor was sent to the Pathology department for routine histopathology and immunohistochemistry [Estrogen receptors , progesterone receptors , Herceptin-2 receptors , and Ki-67] work to confirm the diagnosis.
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