Certain genetic variants may underlie atrial fibrillation alone, a ventricular cardiomyopathy or channelopathy syndrome, or both.
, particularly those with a positive family history and lack of conventional clinical risk factors, because specific genetic variants may underlie AF as well as "potentially more sinister cardiac conditions," a new white paper from the Canadian Cardiovascular Society suggested.
The resulting white paper reviews familial and epidemiologic evidence for a genetic contribution to AF. As an example, the authors pointed to work from the Framingham Heart Study showing a statistically significant risk for AF among first-degree relatives of patients with AF. The overall odds ratio for AF among first-degree relatives was 1.85. But for first-degree relatives of patients with AF onset at younger than age 75 years, the OR increased to 3.23.
Specifically, "a genetic variant could be incorrectly assigned as the cause of AF, which could create confusion for the patient and family members and lead to inappropriate clinical management," said Roberts.
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