Rare but deadly blood clots tied to J&J and AstraZeneca's vaccines were caused by an autoimmune reaction that some people are predisposed to, researchers found.
A health worker administers a dose of the Janssen COVID-19 vaccine to a homeless person during a vaccination campaign in Bangladesh.are but deadly blood clots tied to Johnson & Johnson and AstraZeneca Plc’s Covid-19 shots were caused by an autoimmune reaction that some people are predisposed to, researchers found, a discovery that they say will shape development of future vaccines.
Adenovirus-based vaccines, like the J&J and AstraZeneca shots that were later pulled from the market, contain a component that, in genetically susceptible people, can trigger the production of unusually structured antibodies against a protein involved in blood clotting, scientists said Wednesday in a letter to the New England Journal of Medicine. Researchers plan to identify the culprit and then try to remove it using genetic engineering.
The immune reaction linked to the shot is “a new disease,” he said in an interview. Hematologists and intensive care specialists are likely to spot more cases as they become familiar with it, he said. “It’s a kind of autoimmunity where we know the trigger,” said immunologist James McCluskey, assistant vice chancellor of the University of Melbourne, who wasn’t involved in the research. “That’s unusual. In most cases we never get a handle on the trigger.”A small number of clot-related deaths tied to the AstraZeneca vaccine led to its withdrawal or restriction in Denmark, Norway and other countries in 2021.
Both shots played an important role in vaccine programs during the early stages of the pandemic. One analysis found the Astra vaccine saved an estimatedmade by the Pfizer Inc.-BioNTech SE partnership and Moderna Inc. were later found to be more effective at protecting against Covid and have been updated to tackle more recent virus variants.TIME may receive compensation for some links to products and services on this website. Offers may be subject to change without notice.
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