To better understand why some cancer patients struggle to fight off infections, Georgia Tech researchers have created tiny lab-grown models of human immune systems.
Georgia Institute of Technology Nov 12 2024 To better understand why some cancer patients struggle to fight off infections, Georgia Tech researchers have created tiny lab-grown models of human immune systems.
Ankur Singh, Carl Ring Family Professor in the George W. Woodruff School of Mechanical Engineering and professor in the Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory Designing a tiny immune system model The researchers were inspired to address a critical issue in biomedical science: the poor success rate of translating preclinical findings from animal models into effective clinical outcomes, especially in the context of immunity, infection, and vaccine responses.
The models also enable researchers to control and test immune responses under various conditions. The team discovered that not all tissue sources are the same, and tonsil cells struggled with longevity issues. They used a specialized setup to study how healthy immune cells react to signals that help them fight infections, which failed to trigger the same response in cells from lymphoma survivors who seemingly have recovered from immunotherapy treatment.
"Lymphoma patients treated with CD20-targeted therapies often face increased susceptibility to infections that can persist years after completing therapy.Understanding these long-term impacts on antibody responses could be key to improving both safety and quality of life for lymphoma survivors," said Dr. Jean Koff, associate professor in the department of Hematology and Oncology at Emory University's Winship Cancer Institute and a co-author on the paper.
Immune System Allergy Antibody B Cell Blood Cell CHIP Infectious Diseases Lymphoma Organoids Research Technology Vaccine
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