The sacred image was taken from the Chapel of Magdalene College in Cambridge last week.
The sacred painting of the Virgin and Child was taken from the Chapel of Magdalene College in the city between between 24 and 25 September.
PC Emily-Jayne Matthews, from Cambridgeshire Police, said: "The icon holds great value to those who are connected with it." "We would also like to hear from anyone who may have seen the item for sale or may know of its whereabouts."
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