Bruce William Lynch Jr, 33, is suspected of kidnapping the teenager and is believed to be armed and dangerous.
The FBI is assisting in the investigation to find the missing teenager and has urged anyone who sees the pair to call authorities immediately and not approach them.
The pair are believed to be travelling in a silver-blue 2003 Toyota Matrix and may have left the state of Virginia.Camping gear was reported missing from Lynch's home and they could be staying in areas where they can camp. Mr Love told NBC News that the sheriff's office had received a large number of tip-offs but Isabel and Lynch have still not been found.
During a press conference on Thursday, Isabel's brother begged for her return, saying:"We miss you very much and we want you to come home. I love you forever... I just need my best friend back."Lynch is 5ft 11ins with brown hair, brown eyes and cross tattoos on both upper arms.
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